HCID 86703250, compound → HCID 86703249, compound

HRID 2204428Notes

Reaction equation

HRID 2204428 reaction equation
[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([NH:10][CH:11]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)[C:12]2[N:13]([CH:20]3[CH2:22][CH2:21]3)[CH:14]=[CH:15][C:16]=2[C:17]([OH:19])=O)[CH:3]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[C:7](=[O:8])[N:6]([CH3:9])[CH:5]=[C:4]([N:10]2[C:17](=[O:19])[C:16]3[CH:15]=[CH:14][N:13]([CH:20]4[CH2:21][CH2:22]4)[C:12]=3[CH:11]2[C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)[CH:3]=1

Participants

3

Reactant 1

HCID 86703250HCID 86703250, compound

Product 1

HCID 86703249HCID 86703249, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 240.2 but using 2-(((5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)amino)(4-chlorophenyl)methyl)-1-cyclopropyl-1H-pyrrole-3-carboxylic acid (Step 243.3) and stirring the reaction mixture for 2 hr. tR: 0.99 min (LC-MS 6); ESI-MS: 414.1 [M+H]+ (LC-MS 6); TLC (CH2Cl2/MeOH 95:5): Rf=0.32.

Sources & evidence

ORD record
ord-915be8d483d74cc3bdd8eabafb644de4
Source dataset
uspto-grants-2016_06
Patent number
US09365576B2

Reaction notes

Loading…