Hydrochloric Acid → HCID 66611351, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of phenylmethyl 4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoate (may be prepared as described in Description 34; 305 mg, 0.61 mmol) in tetrahydrofuran (6 ml) was added lithium hydroxide (44.1 mg, 1.84 mmol) and water (1.5 ml). The mixture was stirred at 40° C. overnight, cooled and 2N HCl added. The solvent was removed, water (3 ml) was added and the product filtered to yield the title compound as a white solid which was used directly in the next step without further purification. 170 mg.

Provenance & Evidence