反应详情

温度

40 °C

To a solution of phenylmethyl 4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoate (may be prepared as described in Description 34; 305 mg, 0.61 mmol) in tetrahydrofuran (6 ml) was added lithium hydroxide (44.1 mg, 1.84 mmol) and water (1.5 ml). The mixture was stirred at 40° C. overnight, cooled and 2N HCl added. The solvent was removed, water (3 ml) was added and the product filtered to yield the title compound as a white solid which was used directly in the next step without further purification. 170 mg.

1. temperaturecooled
2. customThe solvent was removed
3. additionwater (3 ml) was added
4. filtrationthe product filtered