Acetic Anhydride → HCID 66611556, compound

HRID 2204703Notes

Reaction equation

HRID 2204703 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:9]([C:13]([F:16])([F:15])[F:14])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[C:17](OC(=O)C)(=[O:19])[CH3:18]>N1C=CC=CC=1>[C:17]([O:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:9]([C:13]([F:14])([F:15])[F:16])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5])(=[O:19])[CH3:18]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 66611706HCID 66611706, compound

Product 1

HCID 66611556HCID 66611556, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Methyl 2-hydroxy-4-methyl-5-(trifluoromethyl)benzoate (may be prepared as described in Description 45; 1.37 g, 5.85 mmol) was dissolved in pyridine (70 ml) and acetic anhydride (1.34 ml, 14.18 mmol) was added. The solution was stirred for 2 hours then the solvent was removed in vacuo to give oil. The oil was purified by column chromatography (SiO2, 3:1 cyclohexane/ethyl acetate) to yield the title compound as a gum. 1.53 g.

Workup

  1. customthe solvent was removed in vacuo
  2. customto give oil
  3. customThe oil was purified by column chromatography (SiO2, 3:1 cyclohexane/ethyl acetate)

Sources & evidence

ORD record
ord-939fddb24ba2407bbea62df8277f28d7
Source dataset
uspto-grants-2016_06
Patent number
US09365551B2

Reaction notes

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