Acetic Anhydride → HCID 66611556, compound

Participants

Reaction Steps

Methyl 2-hydroxy-4-methyl-5-(trifluoromethyl)benzoate (may be prepared as described in Description 45; 1.37 g, 5.85 mmol) was dissolved in pyridine (70 ml) and acetic anhydride (1.34 ml, 14.18 mmol) was added. The solution was stirred for 2 hours then the solvent was removed in vacuo to give oil. The oil was purified by column chromatography (SiO2, 3:1 cyclohexane/ethyl acetate) to yield the title compound as a gum. 1.53 g.

Provenance & Evidence