Hydrochloric Acid → HCID 66611544, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoate (may be prepared as described in Description 49; 248 mg, 0.61 mmol) was dissolved in tetrahydrofuran (4 ml). LiOH (43.8 mg, 1.83 mmol) and water (1 ml) were added and the mixture heated at 40° C. for 2 hours. The mixture was cooled and 2M hydrochloric acid (0.96 ml, 1.91 mmol) was added and the solvent removed in vacuo to give the title compound. 240 mg.

Provenance & Evidence