Hydrochloric Acid → HCID 66611544, compound

HRID 2204706Notes

Reaction equation

HRID 2204706 reaction equation
[N:1]1([CH2:7][C:8]2[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[C:10]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Li+].[OH-].O.Cl>O1CCCC1>[N:1]1([CH2:7][C:8]2[C:17]([C:18]([F:19])([F:21])[F:20])=[CH:16][C:11]([C:12]([OH:14])=[O:13])=[C:10]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:9]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 66612004HCID 66612004, compound

Product 1

HCID 66611544HCID 66611544, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
40 °C

Procedure

Methyl 4-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoate (may be prepared as described in Description 49; 248 mg, 0.61 mmol) was dissolved in tetrahydrofuran (4 ml). LiOH (43.8 mg, 1.83 mmol) and water (1 ml) were added and the mixture heated at 40° C. for 2 hours. The mixture was cooled and 2M hydrochloric acid (0.96 ml, 1.91 mmol) was added and the solvent removed in vacuo to give the title compound. 240 mg.

Workup

  1. temperatureThe mixture was cooled
  2. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-e076e8f420b34868bee1d2aad6616728
Source dataset
uspto-grants-2016_06
Patent number
US09365551B2

Reaction notes

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