Piperidine → HCID 66611811, compound

Participants

Reaction Steps

To a solution of methyl 2-(acetyloxy)-4-(bromomethyl)-5-(trifluoromethyl)benzoate (may be prepared as described in Description 47; 240 mg, 0.68 mmol) in acetone (5 ml) was added triethylamine (0.19 ml, 1.35 mmol) and piperidine (0.09 ml, 0.88 mmol). The solution was stirred for 18 hours. The solvent was removed in vacuo and the residue was taken up in ethyl acetate (10 ml), washed with water (10 ml), dried (MgSO4) and the solvent removed in vacuo to give the title compound. 228 mg.

Provenance & Evidence