Piperidine → HCID 66611811, compound

HRID 2204707Notes

Reaction equation

HRID 2204707 reaction equation
C([O:4][C:5]1[CH:14]=[C:13]([CH2:15]Br)[C:12]([C:17]([F:20])([F:19])[F:18])=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8])(=O)C.C(N(CC)CC)C.[NH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>CC(C)=O>[OH:4][C:5]1[CH:14]=[C:13]([CH2:15][N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[C:12]([C:17]([F:18])([F:19])[F:20])=[CH:11][C:6]=1[C:7]([O:9][CH3:10])=[O:8]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 8471TriethylamineHCID 66611624HCID 66611624, compound

Product 1

HCID 66611811HCID 66611811, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of methyl 2-(acetyloxy)-4-(bromomethyl)-5-(trifluoromethyl)benzoate (may be prepared as described in Description 47; 240 mg, 0.68 mmol) in acetone (5 ml) was added triethylamine (0.19 ml, 1.35 mmol) and piperidine (0.09 ml, 0.88 mmol). The solution was stirred for 18 hours. The solvent was removed in vacuo and the residue was taken up in ethyl acetate (10 ml), washed with water (10 ml), dried (MgSO4) and the solvent removed in vacuo to give the title compound. 228 mg.

Workup

  1. customThe solvent was removed in vacuo
  2. washwashed with water (10 ml)
  3. dry with materialdried (MgSO4)
  4. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-2f1657da453f40b0beb03374b28f2881
Source dataset
uspto-grants-2016_06
Patent number
US09365551B2

Reaction notes

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