Hydrochloric Acid → HCID 66611247, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-[(phenylmethyl)oxy]-4-(1-piperidinylmethyl)-5-(trifluoromethyl)benzoate (may be prepared as described in Description 52; 232 mg, 0.57 mmol) was dissolved in tetrahydrofuran (4 ml) and LiOH (38.8 mg, 1.62 mmol) and water (1 ml) were added. The mixture was heated at 40° C. for 2 hours. The mixture was cooled and 2M hydrochloric acid (0.84 ml, 1.69 mmol) was added and the solvent removed in vacuo to give the title compound as oil. 223 mg.

Provenance & Evidence