Hydrochloric Acid → HCID 66611247, compound

HRID 2204709Notes

Reaction equation

HRID 2204709 reaction equation
[C:1]1([CH2:7][O:8][C:9]2[CH:18]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[C:16]([C:26]([F:29])([F:28])[F:27])=[CH:15][C:10]=2[C:11]([O:13]C)=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Li+].[OH-].O.Cl>O1CCCC1>[C:1]1([CH2:7][O:8][C:9]2[CH:18]=[C:17]([CH2:19][N:20]3[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]3)[C:16]([C:26]([F:29])([F:27])[F:28])=[CH:15][C:10]=2[C:11]([OH:13])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 66611362HCID 66611362, compound

Product 1

HCID 66611247HCID 66611247, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
40 °C

Procedure

Methyl 2-[(phenylmethyl)oxy]-4-(1-piperidinylmethyl)-5-(trifluoromethyl)benzoate (may be prepared as described in Description 52; 232 mg, 0.57 mmol) was dissolved in tetrahydrofuran (4 ml) and LiOH (38.8 mg, 1.62 mmol) and water (1 ml) were added. The mixture was heated at 40° C. for 2 hours. The mixture was cooled and 2M hydrochloric acid (0.84 ml, 1.69 mmol) was added and the solvent removed in vacuo to give the title compound as oil. 223 mg.

Workup

  1. temperatureThe mixture was cooled
  2. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-7e84d24a5c5142a5b9a015016b3849f0
Source dataset
uspto-grants-2016_06
Patent number
US09365551B2

Reaction notes

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