HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 66635249, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Aminopyridazine | HCID 298492 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 66611936 | HCID 66611936 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66635249 | HCID 66635249 | — |
Reaction Steps
2-[(Phenylmethyl)oxy]-4-(1-piperidinylcarbonyl)-5-(trifluoromethyl)benzoic acid (may be prepared as described in Description 58; 70 mg, 0.17 mmol) was dissolved in N,N-dimethylformamide (4 ml). Diisopropylethylamine (0.06 ml, 0.34 mmol) and HATU (131 mg, 0.34 mmol) were added. The mixture was stirred for 5 minutes then 4-pyridazinamine (32.7 mg, 0.34 mmol) was added. The solution was stirred for 90 minutes. The solvent was removed in vacuo and the residue purified by MDAP to give the title compound as a white solid. 30 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365551B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-e877f35538364fffae84f83612a630f6 |
| Source note | uspto-grants-2016_06 |