Diisopropylethylamine → HCID 66635249, compound

HRID 2204761Notes

Reaction equation

HRID 2204761 reaction equation
[C:1]1([CH2:7][O:8][C:9]2[CH:17]=[C:16]([C:18]([N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:19])[C:15]([C:26]([F:29])([F:28])[F:27])=[CH:14][C:10]=2[C:11](O)=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(C(C)C)CC)(C)C.CN(C(O[N:47]1[N:55]=[N:54][C:49]2[CH:50]=[CH:51]C=N[C:48]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.N1C=CC(N)=CN=1>CN(C)C=O>[C:1]1([CH2:7][O:8][C:9]2[CH:17]=[C:16]([C:18]([N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:19])[C:15]([C:26]([F:27])([F:29])[F:28])=[CH:14][C:10]=2[C:11]([NH:54][C:49]2[CH:50]=[CH:51][N:55]=[N:47][CH:48]=2)=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 2984924-AminopyridazineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 66611936HCID 66611936, compound

Product 1

HCID 66635249HCID 66635249, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-[(Phenylmethyl)oxy]-4-(1-piperidinylcarbonyl)-5-(trifluoromethyl)benzoic acid (may be prepared as described in Description 58; 70 mg, 0.17 mmol) was dissolved in N,N-dimethylformamide (4 ml). Diisopropylethylamine (0.06 ml, 0.34 mmol) and HATU (131 mg, 0.34 mmol) were added. The mixture was stirred for 5 minutes then 4-pyridazinamine (32.7 mg, 0.34 mmol) was added. The solution was stirred for 90 minutes. The solvent was removed in vacuo and the residue purified by MDAP to give the title compound as a white solid. 30 mg.

Workup

  1. stirringThe solution was stirred for 90 minutes
  2. customThe solvent was removed in vacuo
  3. customthe residue purified by MDAP

Sources & evidence

ORD record
ord-e877f35538364fffae84f83612a630f6
Source dataset
uspto-grants-2016_06
Patent number
US09365551B2

Reaction notes

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