反应详情

温度

130 °C

Dissolve 1H-pyrazole-4-carboxaldehyde in N,N-dimethylformamide (1.9 mL). Add potassium carbonate (0.539 g, 3.90 mmol) and cyclopropylbromide (0.346 g, 2.86 mmol). Heat in a pressure tube to 130° C. for 18 hr. Cool to ambient temperature and add DCM and water. Separate layers and extract water layer 3 times with DCM. Wash combined DCM layers with brine, dry (magnesium sulfate), filter, and concentrated to give the free base of the title preparation. GC-MS: m/z=136 [M+].

1. temperatureCool to ambient temperature
2. extractionSeparate layers and extract water layer 3 times with DCM
3. washWash
4. dry with materialdry (magnesium sulfate)
5. filtrationfilter
6. concentrationconcentrated
7. customto give the free base of the title
8. custompreparation