HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl isothiocyanate → N-(2-(3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazine-2-carbonyl)hydrazinecarbonothioyl)ethanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl isothiocyanate | HCID 128851 | — |
| Reactant | 3-Amino-6-(4-isopropylsulfonylphenyl)pyrazine-2-carbohydrazide | HCID 59471632 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | N-(2-(3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazine-2-carbonyl)hydrazinecarbonothioyl)ethanamide | HCID 59471667 | — |
Reaction Steps
A mixture of 3-amino-6-(4-isopropylsulfonylphenyl)pyrazine-2-carbohydrazide (100 mg, 0.2982 mmol), acetyl isothiocyanate (30.16 mg, 26.20 μL, 0.2982 mmol) and dry DCE (2.000 mL) were stirred at ambient temperature for 2 h and then concentrated in vacuo. Used directly in the next step without further purification; MS (ES+) 437.20
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09365557B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-043d034c9784469faaa1a138f7c89591 |
| Source note | uspto-grants-2016_06 |