2,3-Dihydro-1,4-benzodioxin-6-carbaldehyde → (2Z)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-{4-[(8-hydroxyoctyl)oxy]phenyl}prop-2-enenitrile

HRID 2204913Notes

Reaction equation

HRID 2204913 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][C:18]#[N:19])=[CH:13][CH:12]=1.[O:20]1[C:25]2[CH:26]=[CH:27][C:28]([CH:30]=O)=[CH:29][C:24]=2[O:23][CH2:22][CH2:21]1>>[O:20]1[C:25]2[CH:26]=[CH:27][C:28](/[CH:30]=[C:17](/[C:14]3[CH:13]=[CH:12][C:11]([O:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][OH:1])=[CH:16][CH:15]=3)\[C:18]#[N:19])=[CH:29][C:24]=2[O:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 2481272,3-Dihydro-1,4-benzodioxin-6-carbaldehydeHCID 71272497HCID 71272497, compound

Product 1

HCID 71272407(2Z)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-{4-[(8-hydroxyoctyl)oxy]phenyl}prop-2-enenitrileYield 41%

Procedure

(2Z)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-{4-[(8-hydroxyoctyl)oxy]phenyl}prop-2-enenitrile is prepared starting from {4-[(8-hydroxyoctyl)oxy]phenyl}acetonitrile and commercial 1,4-Benzodioxan-6-carboxaldehyde according the same procedure following for example 1 in 41% yield.

Sources & evidence

ORD record
ord-4078e22122f64832af8949f379747059
Source dataset
uspto-grants-2016_06
Patent number
US09366906B2

Reaction notes

Loading…