反应详情

To 3′-chloro-2,3,5,6-tetrahydro-[1,2′]bipyrazinyl-4-carboxylic acid t-butyl ester (3.00 g, 10.0 mmol, 1 eq) add a 4 M solution of hydrochloric acid in 1,4-dioxane (100 mL, 400 mmol, 40 eq) and stir at room temperature for 3 hr. Filter precipitate and wash with diethyl ether. Dry the powder in vacuum oven over night to give 3′-chloro-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl dihydrochloride as a pale yellow powder (2.11 g, 78%). MS (ES): m/z=199 [M+H]+.

1. filtrationFilter precipitate
2. washwash with diethyl ether
3. customDry the powder in vacuum oven over night