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HRID2204971

反应详情

EQUATION

反应方程式

HRID 2204971 的结构方程式

REACTANTS

反应物

2
结构：[N-]=[N+]=[N-].[Na+]
HCID33557

未命名化合物

结构：CCCCCCCCCCCCCCCCOC[C@@H](CO[Si](C)(C)C(C)(C)C)OS(C)(=O)=O
HCID86678272

未命名化合物

PRODUCTS

生成物

1
结构：CCCCCCCCCCCCCCCCOC[C@H](CO[Si](C)(C)C(C)(C)C)N=[N+]=[N-]
HCID86678273

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

A mixture of (S)-1-(tert-butyldimethylsilyloxy)-3-(hexadecyloxy)propan-2-yl methanesulfonate (1 eq) and NaN3 (5 eq) in DMF (0.5 M) was stirred at 100° C. over night. The reaction mixture was filtered and washed with DCM. The filtrate was concentrated en vaccuo. The resulting crude was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 0-15% EtOAc/Hex to give (R)-(2-azido-3-(hexadecyloxy)propoxy)(tert-butyl)dimethylsilane as a colorless oil.

WORKUP

后处理

  1. filtrationThe reaction mixture was filtered
  2. washwashed with DCM
  3. concentrationThe filtrate was concentrated en vaccuo
  4. customThe resulting crude was purified by flash chromatography on a COMBIFLASH® system (ISCO)