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HRID2205043

反应详情

EQUATION

反应方程式

HRID 2205043 的结构方程式

REACTANTS

反应物

2
结构：C1CCNCC1
HCID8082

Piperidine

C5H11N

结构：CCCCCCCCCCCCOC[C@H](CSC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)NCCOCCOCCOCCC(=O)OC(C)(C)C)OCCCCCCCCCCCC
HCID86678318

未命名化合物

PRODUCTS

生成物

1
结构：CCCCCCCCCCCCOC[C@H](CSC[C@H](N)C(=O)NCCOCCOCCOCCC(=O)OC(C)(C)C)OCCCCCCCCCCCC
HCID86678317

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1.CN(C)C=O
溶剂HCID21974620

未命名化合物

CONDITIONS

反应条件

温度
25 °C

PROCEDURE

实验过程

To a solution of (15R,19R)-tert-butyl 15-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-19-(dodecyloxy)-14-oxo-4,7,10,21-tetraoxa-17-thia-13-azatritriacontan-1-oate (1 eq) was added 20% piperidine (50 eq) in 4:1 THF/DMF. The resulting solution was stirred for 15 minutes at 25° C. and then concentrated en vaccuo. The crude mixture was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 0-10% MeOH/DCM to give the title product as a white solid.

WORKUP

后处理

  1. concentrationconcentrated en vaccuo
  2. customThe crude mixture was purified by flash chromatography on a COMBIFLASH® system (ISCO)