Ciprofloxacin → HCID 131735801, compound

HRID 2205075Notes

Reaction equation

HRID 2205075 reaction equation
[CH:1]1[C:2]2[C:17](=[O:18])[C:16]([C:19]([OH:21])=[O:20])=[CH:15][N:14]([CH:22]3[CH2:24][CH2:23]3)[C:3]=2[CH:4]=[C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[C:6]=1[F:7].[OH:25][C:26]([CH:28]([C:30]1[CH:39]=[CH:38][C:33]([CH2:34][CH:35]([CH3:37])[CH3:36])=[CH:32][CH:31]=1)[CH3:29])=[O:27]>O>[OH:27][C:26]([CH:28]([C:30]1[CH:31]=[CH:32][C:33]([CH2:34][CH:35]([CH3:36])[CH3:37])=[CH:38][CH:39]=1)[CH3:29])=[O:25].[CH:1]1[C:2]2[C:17](=[O:18])[C:16]([C:19]([OH:21])=[O:20])=[CH:15][N:14]([CH:22]3[CH2:23][CH2:24]3)[C:3]=2[CH:4]=[C:5]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[C:6]=1[F:7]

Participants

4

Reactant 2

HCID 2764CiprofloxacinHCID 3672Ibuprofen, (+-)-

Product 1

HCID 131735801HCID 131735801, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

300 mg of ibuprofen was heated in a beaker under stirring to melt. Once molten, lecithin was added to the molten ibuprofen to form a 0.01-5% W/V emulsion of lecithin in ibuprofen. 200 mg ciprofloxacin was then added to the molten dispersion of ibuprofen and lecithin. Once a clear molten solution was formed, approximately 50 mL deionized water (preheated to 80° C.) was added to the mixture. The mixture was stirred at an elevated temperature until a homogenous emulsion was formed. The emulsion was subsequently cooled to room temperature, and lyophilized or centrifuged to retrieve micronized particles.

Workup

  1. customOnce a clear molten solution was formed
  2. additionwas added to the mixture
  3. customwas formed

Sources & evidence

ORD record
ord-998aa9214d22416ca9670d8989d7f34a
Source dataset
uspto-grants-2016_06
Patent number
US09370514B2

Reaction notes

Loading…