Ciprofloxacin → HCID 131735801, compound

Participants

Reaction Steps

300 mg of ibuprofen was heated in a beaker under stirring to melt. Once molten, lecithin was added to the molten ibuprofen to form a 0.01-5% W/V emulsion of lecithin in ibuprofen. 200 mg ciprofloxacin was then added to the molten dispersion of ibuprofen and lecithin. Once a clear molten solution was formed, approximately 50 mL deionized water (preheated to 80° C.) was added to the mixture. The mixture was stirred at an elevated temperature until a homogenous emulsion was formed. The emulsion was subsequently cooled to room temperature, and lyophilized or centrifuged to retrieve micronized particles.

Provenance & Evidence