Hydrochloric Acid → HCID 86718103, compound

HRID 2205101Notes

Reaction equation

HRID 2205101 reaction equation
[C:1]1([C:7]2[C:16]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=3)=[N:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:27]([O:29]C)=[O:28])[CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl>CO>[C:1]1([C:7]2[C:16]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([F:24])([F:25])[F:26])=[CH:19][CH:18]=3)=[N:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:27]([OH:29])=[O:28])[CH:13]=3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86718102HCID 86718102, compound

Product 1

HCID 86718103HCID 86718103, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

A solution of methyl 2-phenyl-3-(4-(trifluoromethyl)phenyl)quinoxaline-6-carboxylate (80 mg, 0.20 mmol, 1.00 equiv) in MeOH (10 mL) and NaOH (23.5 mg, 3.00 equiv) was placed in a 50-mL round-bottom flask and allowed to react, with stirring, for 3 hrs while the temperature was maintained at 50° C. in an oil bath. The pH value of the solution was adjusted to 3 with HCl (2N). The resulting solids were collected by filtration, yielding 35 mg (45%) of 2-phenyl-3-(4-(trifluoromethyl)phenyl)quinoxaline-6-carboxylic acid as a yellow solid.

Workup

  1. customto react
  2. filtrationThe resulting solids were collected by filtration

Sources & evidence

ORD record
ord-94e04dd5f0fd486aaadab9b41f08119a
Source dataset
uspto-grants-2016_06
Patent number
US09370522B2

Reaction notes

Loading…