4-Amino-2-hydroxy-5-nitrobenzoic acid → 4,5-Diamino-2-hydroxybenzoic acid

HRID 2205118Notes

Reaction equation

HRID 2205118 reaction equation
[NH2:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:14])[CH:3]=1>CC(O)=O.[Pd]>[NH2:1][C:2]1[C:10]([NH2:11])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([OH:14])[CH:3]=1

Participants

4

Reactant 1

HCID 218421914-Amino-2-hydroxy-5-nitrobenzoic acid

Product 1

HCID 131586084,5-Diamino-2-hydroxybenzoic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

Under an H2(g) atmosphere, a suspension of 4-amino-2-hydroxy-5-nitrobenzoic acid (200 mg, 1.01 mmol, 1.00 equiv) and Pd/C (anhydrous) (0.1 g) in HOAc (15 mL) in a 50-mL round-bottom flask was allowed to react, with stirring, overnight at room temperature. The resulting solution was directly taken on to the next step without further purification.

Workup

  1. customto react
  2. customThe resulting solution was directly taken on to the next step without further purification

Sources & evidence

ORD record
ord-c8e11cca5aa645de84043ab848f77ef1
Source dataset
uspto-grants-2016_06
Patent number
US09370522B2

Reaction notes

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