Aluminium lithium hydride → HCID 86718134, compound

HRID 2205149Notes

Reaction equation

HRID 2205149 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH3:7][O:8][C:9]1[CH:10]=[C:11]([C:15]2[C:16]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[N:17][C:18]3[C:23]([N:24]=2)=[CH:22][C:21]([C:25](OC)=[O:26])=[CH:20][CH:19]=3)[CH:12]=[CH:13][CH:14]=1>C1COCC1>[CH3:7][O:8][C:9]1[CH:10]=[C:11]([C:15]2[C:16]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[N:17][C:18]3[C:23]([N:24]=2)=[CH:22][C:21]([CH2:25][OH:26])=[CH:20][CH:19]=3)[CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 86718135HCID 86718135, compound

Product 1

HCID 86718134HCID 86718134, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

LiAlH4 (10 mg, 0.26 mmol, 2.00 equiv) was added to a solution of methyl 3-(3-methoxyphenyl)-2-phenylquinoxaline-6-carboxylate (50 mg, 0.14 mmol, 1.00 equiv) in THF (30 mL) at 0° C. The resulting solution was allowed to react, with stifling, for 2 hrs at room temperature. The reaction was quenched by the addition of 10 mL of ethyl acetate. The solids were filtered out, and the filtrate was concentrated under vacuum, affording 30 mg (65%) of (3-(3-methoxyphenyl)-2-phenylquinoxalin-6-yl)methanol as a white solid.

Workup

  1. customto react
  2. customThe reaction was quenched by the addition of 10 mL of ethyl acetate
  3. filtrationThe solids were filtered out
  4. concentrationthe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-b703971332044b069862e80529efa0fd
Source dataset
uspto-grants-2016_06
Patent number
US09370522B2

Reaction notes

Loading…