HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-amino-1-((2R,3S,4S,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-5-(difluoromethyl)-3-hydroxy-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-(benzyloxy)-5-(benzyloxymethyl)-5-(difluoromethyl)-tetrahydrofuran-3-yl acetate | HCID 118294215 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 4-amino-1-((2R,3S,4S,5R)-4-(benzyloxy)-5-(benzyloxymethyl)-5-(difluoromethyl)-3-hydroxy-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one | HCID 118294393 | — |
Reaction Steps
A solution of compound 36 (0.112 g, 0.21 mmol) in NH3.MeOH (4 mL) was stirred at 60° C. for 12 h and then cooled and evaporated to dryness under reduced pressure to give 37 as a white solid. LC-MS: (M+H)+=474.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09370569B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-6b1e484cf78042cbb58fb751791b8056 |
| Source note | uspto-grants-2016_06 |