Ammonium Chloride → HCID 68595789, compound

HRID 220525Notes

Reaction equation

HRID 220525 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([N:14]3[CH2:19][CH2:18][N:17]([C:20]([C:22]4[CH:23]=[N:24][N:25]([CH:27]([CH3:29])[CH3:28])[CH:26]=4)=O)[CH2:16][CH2:15]3)=[N:10][CH:11]=[CH:12][N:13]=2)=[CH:4][CH:3]=1.[Cl-:30].[NH4+]>CO>[ClH:30].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([N:14]3[CH2:19][CH2:18][N:17]([CH2:20][C:22]4[CH:23]=[N:24][N:25]([CH:27]([CH3:29])[CH3:28])[CH:26]=4)[CH2:16][CH2:15]3)=[N:10][CH:11]=[CH:12][N:13]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 68594535HCID 68594535, compound

Product 1

HCID 68595789HCID 68595789, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Prepare the title compound using the methods of Example 135 starting with [3′-(4-fluorophenyl)-2,3,5,6-tetrahydro-[1,2′]bipyrazinyl-4-yl]-(1-isopropyl-1H-pyrazol-4-yl)-methanone (94 mg, 47%). Dissolve the free base (0.087 g, 0.229 mmol) in methanol and add a solution of ammonium chloride (0.012 g, 0.229 mmol) in a minimal volume of methanol. Shake for 18 hr. at room temperature and concentrate to give the title compound (94 mg, 99%). MS (ES): m/z=381 [M+H]+.

Workup

  1. concentrationat room temperature and concentrate

Sources & evidence

ORD record
ord-64832857ed8e429ea95b7a38e76aae4c
Source dataset
uspto-grants-2012_06
Patent number
US08202873B2

Reaction notes

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