HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetaldehyde → rac-(E)-14,16-Dimethyloxacyclohexadec-13-en-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetaldehyde | HCID 177 | — |
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | 2-(Prop-1-en-2-yl)cyclododecanone | HCID 13582448 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | rac-(E)-14,16-Dimethyloxacyclohexadec-13-en-2-one | HCID 89525617 | 88% |
Reaction Steps
Following the general procedure as described in Example 1, 2-(prop-1-en-2-yl)cyclododecanone (2.22 g, 10 mmol), acetaldehyde (0.53 g, 12 mmol) and boron trifluoride etherate (0.14 g, 1.0 mmol) in 1,2-dichloroethane (10 mL) were reacted to give the title product as a colorless liquid (2.34 g, 88% yield. Mixture of E/Z isomers in a ratio of 8:1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371262B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-63d48bc46497453196f8fd449817126a |
| Source note | uspto-grants-2016_06 |