Trifluoroacetic acid → HCID 178507170, compound

HRID 2205292Notes

Reaction equation

HRID 2205292 reaction equation
C(OC(=O)[NH:7][C:8]1([C:13]2[NH:17][C:16]3[CH:18]=[CH:19][C:20]([Cl:22])=[CH:21][C:15]=3[N:14]=2)[CH2:12][CH2:11][O:10][CH2:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:22][C:20]1[CH:19]=[CH:18][C:16]2[NH:17][C:13]([C:8]3([NH2:7])[CH2:12][CH2:11][O:10][CH2:9]3)=[N:14][C:15]=2[CH:21]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178452617HCID 178452617, compound

Product 1

HCID 178507170HCID 178507170, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[3-(5-Chloro-1H-benzoimidazol-2-yl)-tetrahydro-furan-3-yl]-carbamic acid tert-butyl ester (2.09 g, 6.19 mmol) is dissolved in DCM (100 mL) and treated with TFA (10 mL). Stirring is continued for 2 h. Volatiles are evaporated under reduced pressure and the resulting residue taken up twice with ethyl ether and evaporated under reduced pressure to give 3-(5-Chloro-1H-benzoimidazol-2-yl)-tetrahydro-furan-3-ylamine as trifluoroacetic salt crude (2.2 g).

Workup

  1. customVolatiles are evaporated under reduced pressure
  2. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-e6997fc9f2cd45cda810fe20cd479084
Source dataset
uspto-grants-2016_06
Patent number
US09371282B2

Reaction notes

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