反应详情

Starting material: N4-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine was prepared according to the same method of the preparation of N4-(3-chloro-4-fluorophenyl)-7-(2-methoxy)ethoxyquinazoline-4,6-diamine in WO2008/33747, but starting material was 4-chloro-7-ethoxy-6-nitro-quinazoline (Bioorg. Med. Chem, 2007, 15, 3635-3648); other materials were prepared as example 1.

1. customother materials were prepared as example 1