HuagongsheHuagongshe Chemistry Print Report · For research reference only
N4-(3-Chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine → N4-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N4-(3-Chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine | HCID 18765584 | — |
| Reactant | 4-Chloro-7-ethoxy-6-nitroquinazoline | HCID 86727276 | — |
| Product | N4-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine | HCID 66584354 | — |
Reaction Steps
Starting material: N4-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine was prepared according to the same method of the preparation of N4-(3-chloro-4-fluorophenyl)-7-(2-methoxy)ethoxyquinazoline-4,6-diamine in WO2008/33747, but starting material was 4-chloro-7-ethoxy-6-nitro-quinazoline (Bioorg. Med. Chem, 2007, 15, 3635-3648); other materials were prepared as example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09371292B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-5038da78166b47dfa7a634de9166bf50 |
| Source note | uspto-grants-2016_06 |