4-Methyl-3-nitrobenzenesulfonyl chloride → N-[5-chloro-2-(methylthio)phenyl]-4-methyl-3-nitrobenzenesulfonamide

HRID 2205384Notes

Reaction equation

HRID 2205384 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:9][CH3:10])=[C:6]([NH2:8])[CH:7]=1.[CH3:11][C:12]1[CH:17]=[CH:16][C:15]([S:18](Cl)(=[O:20])=[O:19])=[CH:14][C:13]=1[N+:22]([O-:24])=[O:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:9][CH3:10])=[C:6]([NH:8][S:18]([C:15]2[CH:16]=[CH:17][C:12]([CH3:11])=[C:13]([N+:22]([O-:24])=[O:23])[CH:14]=2)(=[O:19])=[O:20])[CH:7]=1

Participants

3

Reactant 2

HCID 5606384-Methyl-3-nitrobenzenesulfonyl chlorideHCID 27945775-Chloro-2-(methylthio)aniline

Product 1

HCID 57378643N-[5-chloro-2-(methylthio)phenyl]-4-methyl-3-nitrobenzenesulfonamideYield 61%

Procedure

Following General Procedure B, the title compound (197 mg, 61%) was prepared from 5-Chloro-2-methylsulfanyl-phenylamine (150 mg, 0.87 mmol) and 4-Methyl-3-nitro-benzenesulfonyl chloride (235 mg, 0.87 mmol).

Sources & evidence

ORD record
ord-7cc7734085dc4fbbb126b32709dda097
Source dataset
uspto-grants-2016_06
Patent number
US09371278B2

Reaction notes

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