Dimethylformamide dimethyl acetal → HCID 178516659, compound

HRID 2205402Notes

Reaction equation

HRID 2205402 reaction equation
C[N:2](C)[CH:3]=[N:4][C:5]([C:7]1[C:12]([S:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:11][C:10](=[O:20])[N:9]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:8]=1)=O.O=C1N(C2C=CC=CC=2)[N:33]=C(C(N)=O)C(SC2C=CC=CC=2)=C1.COC(OC)N(C)C>>[C:21]1([N:9]2[C:10](=[O:20])[CH:11]=[C:12]([S:13][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:7]([C:5]3[N:4]=[CH:3][NH:2][N:33]=3)=[N:8]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 78373Dimethylformamide dimethyl acetalHCID 68292689HCID 68292689, compoundHCID 68292857HCID 68292857, compound

Product 1

HCID 178516659HCID 178516659, compound

Conditions

Temperature
120 °C

Procedure

Preparation of N,N-dimethyl-N′-[(6-oxo-1-phenyl-4-phenylsulfanyl-1,6-dihydropyridazin-3-yl)carbonyl]formamidine: A mixture of 6-oxo-1-phenyl-4-phenylsulfanyl-1,6-dihydropyridazine-3-carboxamide (193 mg, 0.6 mmol) and N,N-dimethylformamide dimethyl acetal (1 mL) was stirred at 120° C. for 1 h and then evaporated in vacuo. The residue was crystallized on treatment with Et2O (10 mL) to yield the desired product as a white crystalline substance (196 mg, 88%).

Workup

  1. customevaporated in vacuo
  2. customThe residue was crystallized on treatment with Et2O (10 mL)

Sources & evidence

ORD record
ord-1c626f4a44eb410ab8864e6839fb4b18
Source dataset
uspto-grants-2016_06
Patent number
US09371290B2

Reaction notes

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