Ethylene Glycol → HCID 178455329, compound

HRID 2205649Notes

Reaction equation

[Si:1]([O:8][C@@H:9]1[CH2:14][CH2:13][C@H:12]([N:15]2[CH2:19][CH2:18][C@:17]3([CH2:24][CH2:23][CH2:22][NH:21][CH2:20]3)[C:16]2=[O:25])[CH2:11][CH2:10]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[Br:26][C:27]1[CH:32]=[CH:31][C:30](I)=[C:29]([Cl:34])[CH:28]=1.P([O-])([O-])([O-])=O.[K+].[K+].[K+].C(O)CO>C(O)CCC.[Cu]I>[Br:26][C:27]1[CH:32]=[CH:31][C:30]([N:21]2[CH2:22][CH2:23][CH2:24][C@@:17]3([C:16](=[O:25])[N:15]([C@H:12]4[CH2:13][CH2:14][C@@H:9]([O:8][Si:1]([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:3])[CH3:2])[CH2:10][CH2:11]4)[CH2:19][CH2:18]3)[CH2:20]2)=[C:29]([Cl:34])[CH:28]=1

Participants

Conditions

Temperature: 100 °C

Procedure

A mixture of (5S)-2-(cis-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-2,7-diazaspiro[4.5]decan-1-one (0.282 g, 0.000769 mol), 4-bromo-2-chloro-1-iodobenzene (0.293 g, 0.000922 mol) (Lancaster, cat #: 19245), copper(I) iodide (0.015 g, 0.000077 mol), potassium phosphate (0.490 g, 0.00231 mol) and 1,2-ethanediol (0.0857 mL, 0.00154 mol) in 1-butanol (0.75 mL) was heated at 100° C. under nitrogen for 2 d. The reaction mixture was filtered, concentrated under reduced pressure, and the residue was purified by flash chromatography on a silica gel column (eluting with 0 to 50% ethyl acetate in hexanes) to afford the desired product.

Workup

filtrationThe reaction mixture was filtered
concentrationconcentrated under reduced pressure
customthe residue was purified by flash chromatography on a silica gel column (eluting with 0 to 50% ethyl acetate in hexanes)

Sources & evidence

ORD record: ord-d65a674e4a2b4f05af291e7a66df27a4
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09371323B2

Reaction notes

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