Acetic Acid → HCID 90036302, compound

HRID 2205667Notes

Reaction equation

HRID 2205667 reaction equation
[CH3:1][O:2][C:3]1[C:12]([C:13]([NH:15][NH:16]C(OC(C)(C)C)=O)=[O:14])=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.C(O)(=O)C>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:12]([C:13]([NH:15][NH2:16])=[O:14])=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 90036206HCID 90036206, compound

Product 1

HCID 90036302HCID 90036302, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

tert-Butyl 2-(2-methoxyquinoline-3-carbonyl)hydrazinecarboxylate (1.23 g, 3.87 mmol) was dissolved in DCM (10 mL) and cooled to 0° C. Trifluoroacetic acetic acid (10 mL) was added and the mixture was stirred at room temperature for 1 h. Solvents were evaporated and the residue was washed with water. The product was used without purification in the next step. MS (ES) C11H11N3O2 requires: 217.22, found: 218.

Workup

  1. customSolvents were evaporated
  2. washthe residue was washed with water
  3. customThe product was used without purification in the next step

Sources & evidence

ORD record
ord-5c2fae08d5d94d88ad7af3ce2a94f4f2
Source dataset
uspto-grants-2016_06
Patent number
US09371295B2

Reaction notes

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