Hydrazine hydrate (1:1) → N-(4-(6-hydrazinylpyridazin-3-yl)phenyl)methanesulfonamide

HRID 2205728Notes

Reaction equation

HRID 2205728 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.O.[NH2:20][NH2:21]>>[NH:20]([C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1)[NH2:21]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86650228N-(4-(6-chloropyridazin-3-yl)phenyl)methanesulfonamide

Product 1

HCID 66849307N-(4-(6-hydrazinylpyridazin-3-yl)phenyl)methanesulfonamide

Procedure

A suspension of N-(4-(6-chloropyridazin-3-yl)phenyl)methanesulfonamide (2.82 mmole) in hydrazine monohydrate (6 mL) was heated at 120 C for 1 hour and evaporated in vacuo. The residue was dissolved in dichloromethane, washed with water, dried over Na2SO4, and evaporated in vacuo to afford N-(4-(6-hydrazinylpyridazin-3-yl)phenyl)methanesulfonamide.

Workup

  1. temperaturewas heated at 120 C for 1 hour
  2. customevaporated in vacuo
  3. dissolutionThe residue was dissolved in dichloromethane
  4. washwashed with water
  5. dry with materialdried over Na2SO4
  6. customevaporated in vacuo

Sources & evidence

ORD record
ord-4f948cb74dec416c985330b0db71b059
Source dataset
uspto-grants-2016_06
Patent number
US09371329B2

Reaction notes

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