反应详情

温度

90 °C

A mixture of N-[3-phenyl-4-(2-phenylethynyl)-1H-pyrazol-5-yl]acetamide (12.5 g, 42 mmol), ethanol (100 mL) and 25% aq. NaOH solution (100 mL) was stirred and heated to 90° C. for 1 h and cooled to room temperature. The reaction mixture was diluted with ethyl acetate and water. The organic phase was washed with water and brine, dried (phase separator cartridge) and concentrated in vacuo. Diethyl ether was added to the residue and the solid was collected by filtration, washed with diethyl ether and dried in vacuo to provide the title compound as a solid (5.4 g).

1. temperaturecooled to room temperature
2. washThe organic phase was washed with water and brine
3. customdried (phase separator cartridge)
4. concentrationconcentrated in vacuo
5. additionDiethyl ether was added to the residue
6. filtrationthe solid was collected by filtration
7. washwashed with diethyl ether
8. customdried in vacuo