N-(2-Hydroxyethyl)imidazole → 4-Chloro-3-(3-fluorophenyl)-1-(2-imidazol-1-ylethyl)-5-phenyl-pyrazolo[3,4-c]pyridazine

HRID 2205822Notes

Reaction equation

HRID 2205822 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[NH:14][N:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=3)[C:3]=12.[N:24]1([CH2:29][CH2:30]O)[CH:28]=[CH:27][N:26]=[CH:25]1>>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[N:14]([CH2:30][CH2:29][N:24]3[CH:28]=[CH:27][N:26]=[CH:25]3)[N:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=3)[C:3]=12

Participants

3

Reactant 2

HCID 74168N-(2-Hydroxyethyl)imidazoleHCID 86717314CID 86717314

Product 1

HCID 901318044-Chloro-3-(3-fluorophenyl)-1-(2-imidazol-1-ylethyl)-5-phenyl-pyrazolo[3,4-c]pyridazine

Procedure

Compound IIs was synthesized from 4-chloro-3-(3-fluorophenyl)-5-phenyl-1H-pyrazolo[3,4-c]pyridazine and 2-(1H-imidazol-1-yl)ethanol following the general procedure for the Mitsunobu reaction as described above.

Workup

  1. customfor the Mitsunobu reaction

Sources & evidence

ORD record
ord-de2f6ea53d074c42b595467d59dca104
Source dataset
uspto-grants-2016_06
Patent number
US09371332B2

Reaction notes

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