Hydrogen chloride-ethyl acetate → oxan-3-ylhydrazine dihydrochloride

HRID 2206025Notes

Reaction equation

HRID 2206025 reaction equation
[O:1]1[CH2:6][CH2:5][CH2:4][CH:3]([NH:7][NH:8]C(OC(C)(C)C)=O)[CH2:2]1.C(OCC)(=O)C.[ClH:22]>>[ClH:22].[ClH:22].[O:1]1[CH2:6][CH2:5][CH2:4][CH:3]([NH:7][NH2:8])[CH2:2]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66745297tert-Butyl 2-(tetrahydro-2H-pyran-3-yl)hydrazinecarboxylate

Product 1

HCID 75481636oxan-3-ylhydrazine dihydrochloride

Procedure

tert-Butyl 2-(tetrahydro-2H-pyran-3-yl)hydrazinecarboxylate (3.65 g) was dissolved in 4N hydrogen chloride-ethyl acetate solution (85 mL) under ice-cooling, and the solution was stirred overnight, at room temperature. The reaction mixture was concentrated under reduced pressure to give the title compound (2.40 g).

Workup

  1. temperaturecooling
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-396cdd7087e6472b96c0ae7e734f85e7
Source dataset
uspto-grants-2016_06
Patent number
US09371320B2

Reaction notes

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