Hydrogen chloride-ethyl acetate → oxan-3-ylhydrazine dihydrochloride

Participants

Reaction Steps

tert-Butyl 2-(tetrahydro-2H-pyran-3-yl)hydrazinecarboxylate (3.65 g) was dissolved in 4N hydrogen chloride-ethyl acetate solution (85 mL) under ice-cooling, and the solution was stirred overnight, at room temperature. The reaction mixture was concentrated under reduced pressure to give the title compound (2.40 g).

Provenance & Evidence