Hydrazine hydrate (1:1) → HCID 178494031, compound

HRID 2206065Notes

Reaction equation

HRID 2206065 reaction equation
[Br:1][C:2]1[C:3]([C:11]([CH:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=O)=[C:4](F)[C:5]([O:8][CH3:9])=[N:6][CH:7]=1.O.[NH2:19][NH2:20]>CO>[Br:1][C:2]1[CH:7]=[N:6][C:5]([O:8][CH3:9])=[C:4]2[NH:19][N:20]=[C:11]([CH:13]3[CH2:17][CH2:16][CH2:15][CH2:14]3)[C:3]=12

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 117987725HCID 117987725, compound

Product 1

HCID 178494031HCID 178494031, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (5-bromo-3-fluoro-2-methoxypyridin-4-yl)(cyclopentyl)methanone (440 mg) in methanol (10 mL) was added hydrazine monohydrate (2.06 mL) at room temperature, the mixture was stirred for 3 hr, and the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (basic silica gel, ethyl acetate/hexane) to give the title compound (100 mg).

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (basic silica gel, ethyl acetate/hexane)

Sources & evidence

ORD record
ord-a1a493bac9664048be69d6045ceb950f
Source dataset
uspto-grants-2016_06
Patent number
US09371320B2

Reaction notes

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