Water → HCID 117988134, compound

HRID 2206079Notes

Reaction equation

HRID 2206079 reaction equation
[C:1]1([C:6]2[C:14]3[C:9](=[C:10]([O:15][CH3:16])[N:11]=[CH:12][CH:13]=3)[N:8]([C:17]3[CH:22]=[CH:21][C:20]([S:23]([NH2:26])(=[O:25])=[O:24])=[CH:19][CH:18]=3)[N:7]=2)[CH2:5][CH2:4][CH2:3][CH:2]=1.O>CO.[Pd]>[CH:1]1([C:6]2[C:14]3[C:9](=[C:10]([O:15][CH3:16])[N:11]=[CH:12][CH:13]=3)[N:8]([C:17]3[CH:18]=[CH:19][C:20]([S:23]([NH2:26])(=[O:24])=[O:25])=[CH:21][CH:22]=3)[N:7]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 2

HCID 962WaterHCID 117988445HCID 117988445, compound

Product 1

HCID 117988134HCID 117988134, compoundYield 135.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 4-(3-(cyclopent-1-en-1-yl)-7-methoxy-1H-pyrazolo[3,4-c]pyridin-1-yl)benzenesulfonamide (22 mg) in methanol (10 mL) was added 10% palladium/carbon (6.32 mg) containing water, and the mixture was stirred overnight under hydrogen atmosphere at room temperature. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (30 mg).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-50da4e9def294638ab9aa1bf3b7e26c5
Source dataset
uspto-grants-2016_06
Patent number
US09371320B2

Reaction notes

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