Hydrogen chloride-ethyl acetate → HCID 137010613, compound

HRID 2206224Notes

Reaction equation

HRID 2206224 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N:9]1[C:17]2[CH:16]=[CH:15][NH:14][C:13](=[O:18])[C:12]=2[C:11]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][N:26]3[CH2:30][CH2:29][C:28]([F:32])([F:31])[CH2:27]3)[CH:20]=2)=[N:10]1.C(OC(=O)C)C.[ClH:39]>C(OCC)(=O)C>[ClH:39].[F:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[N:9]1[C:17]2[CH:16]=[CH:15][NH:14][C:13](=[O:18])[C:12]=2[C:11]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][N:26]3[CH2:30][CH2:29][C:28]([F:31])([F:32])[CH2:27]3)[CH:20]=2)=[N:10]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 137010614HCID 137010614, compound

Product 1

HCID 137010613HCID 137010613, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 1-(2,6-difluorophenyl)-3-(3-((3,3-difluoropyrrolidin-1-yl)methyl)phenyl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one (41 mg) obtained in Example 261 in ethyl acetate (2 mL) was added 4M hydrogen chloride ethyl acetate (0.024 mL), and the mixture was stirred at room temperature for 5 min. The precipitate was collected by filtration, and washed with ethyl acetate and hexane to give the title compound (34 mg).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with ethyl acetate and hexane

Sources & evidence

ORD record
ord-4b1be2204c7f4dbb8f0bc02d9d56be0d
Source dataset
uspto-grants-2016_06
Patent number
US09371320B2

Reaction notes

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