HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2206239Generated: October 30, 2026
Hydrazine hydrate (1:1) → 4-chloro-1H-pyrazolo[4,3-c]pyridine
https://huagongshe.com/reaction/2206239
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2,4-Dichloropyridine-3-carbaldehyde | HCID 15053985 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 4-chloro-1H-pyrazolo[4,3-c]pyridine | HCID 46835637 | 65.5% |
Reaction Steps
To a solution of 2,4-dichloropyridine-3-carbaldehyde (7.0 g) in DME (70 mL) was added hydrazine monohydrate (8.0 g) at room temperature. The reaction mixture was stirred overnight at 75° C., and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give the title compound (4.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09371320B2 |
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| Source dataset | uspto-grants-2016_06 |
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| ORD ID | ord-7f68ff6a687a4beabe077440bd05a565 |
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| Source note | uspto-grants-2016_06 |
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