反应详情

温度

75 °C

To a solution of 2,4-dichloropyridine-3-carbaldehyde (7.0 g) in DME (70 mL) was added hydrazine monohydrate (8.0 g) at room temperature. The reaction mixture was stirred overnight at 75° C., and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give the title compound (4.0 g).

1. concentrationconcentrated under reduced pressure
2. customThe residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether)