反应详情

温度

80 °C

A mixture of ethyl 1-benzyl-5,5-difluoro-4-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxylate (5.0 g) and conc. hydrochloric acid (40 mL) in 1,4-dioxane (15 mL) was stirred at 80° C. for 3 hr. The reaction mixture was concentrated under reduced pressure, and diluted with ethyl acetate, and the mixture was adjusted to pH-9 with saturated aqueous sodium carbonate solution. The aqueous layer was extracted with ethyl acetate, and the organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was washed with dichloromethane to give the title compound (1.40 g).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additiondiluted with ethyl acetate
3. extractionThe aqueous layer was extracted with ethyl acetate
4. dry with materialthe organic layer was dried over anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure
6. washThe residue was washed with dichloromethane