Hydrochloric Acid → HCID 3121076, compound

HRID 2206272Notes

Reaction equation

HRID 2206272 reaction equation
[NH2:1][C:2]1[O:3][C:4]2[C:9]([CH:10]([C:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17]([O:22]CC4C=CC=CC=4)=[C:16]([Br:30])[CH:15]=3)[C:11]=1[C:12]#[N:13])=[CH:8][CH:7]=[C:6]1[CH:31]=[CH:32][CH:33]=[CH:34][C:5]=21.Cl>C(O)(=O)C.O>[NH2:1][C:2]1[O:3][C:4]2[C:9]([CH:10]([C:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17]([OH:22])=[C:16]([Br:30])[CH:15]=3)[C:11]=1[C:12]#[N:13])=[CH:8][CH:7]=[C:6]1[CH:31]=[CH:32][CH:33]=[CH:34][C:5]=21

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 69081849HCID 69081849, compound

Product 1

HCID 3121076HCID 3121076, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

2-Amino-4-(4-benzyloxy-3-bromo-5-methoxy-phenyl)-4H-benzo[h]chromene-3-carbonitrile (2) (2 g, 3.89 mmol) was taken in 20 ml acetic acid and charged with 10M hydrochloric acid (10 ml) under vigorous stirring at room temperature, and stirred further at room temperature until the reaction was complete. The reaction mixture was then diluted with 50 ml water, stirred for 3 h at room temperature, thus formed solids were separated by filtration, washed with water and then dried under high vacuum (1.61 g, 3.8 mmol, 97.8%).

Workup

  1. stirringstirred further at room temperature until the reaction
  2. stirringstirred for 3 h at room temperature
  3. customthus formed solids were separated by filtration
  4. washwashed with water
  5. customdried under high vacuum (1.61 g, 3.8 mmol, 97.8%)

Sources & evidence

ORD record
ord-7bcb69396bea4dabbdec2cdb7476ccff
Source dataset
uspto-grants-2016_06
Patent number
US09371333B2

Reaction notes

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