反应详情

温度

80 °C

4-Hydroxy-2,6-dimethylpyrimidine (546 mg, 4.4 mmol), 3-bromo-4,5-dimethoxy-benzaldehyde (1077 mg, 4.4 mmol) and malononitrile (295 mg, 4.4 mmol) were taken in 2 ml ethanol at room temperature, charged with DABCO (48.4 μl, 1.46 mmol) and then stirred at 80° C. under LC-MS control for 18 h. The reaction mixture was then cooled down to room temperature. The mixture was diluted with water to about 100 ml, stirred at room temperature for 1 h and the precipitates were separated by filtration. It was washed well with 50% aqueous ethanol and dried under vacuum (1.52 g, 3.64 mmol, 82.8%).

1. temperatureThe reaction mixture was then cooled down to room temperature
2. stirringstirred at room temperature for 1 h
3. customthe precipitates were separated by filtration
4. washIt was washed well with 50% aqueous ethanol
5. customdried under vacuum (1.52 g, 3.64 mmol, 82.8%)