Tetrahydrofuran → HCID 136344334, compound

HRID 2206286Notes

Reaction equation

HRID 2206286 reaction equation
[NH2:1][C:2]1[O:3][C:4]2[C:9]([CH:10]([C:16]3[CH:21]=[C:20]([O:22][CH3:23])[C:19]([O:24][CH3:25])=[C:18]([Br:26])[CH:17]=3)[C:11]=1[C:12]([NH:14][OH:15])=[NH:13])=[CH:8][CH:7]=[C:6]1[CH:27]=[CH:28][CH:29]=[CH:30][C:5]=21.[O:31]1CCC[CH2:32]1>O>[NH2:1][C:2]1[O:3][C:4]2[C:9]([CH:10]([C:16]3[CH:21]=[C:20]([O:22][CH3:23])[C:19]([O:24][CH3:25])=[C:18]([Br:26])[CH:17]=3)[C:11]=1[C:12]1[NH:13][C:32](=[O:31])[O:15][N:14]=1)=[CH:8][CH:7]=[C:6]1[CH:27]=[CH:28][CH:29]=[CH:30][C:5]=21

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 178487567HCID 178487567, compound

Product 1

HCID 136344334HCID 136344334, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Amino-4-(3-bromo-4,5-dimethoxy-phenyl)-N-hydroxy-4H-benzo[h]chromene-3-carboxamidine (21), (118 mg, 0.25 mmol) and diimidazole carbonyl (40.5 mg, 0.25 mmol) are suspended in 10 ml tetrahydrofuran at room temperature and then is stirred under LC-MS control under heating. The reaction mixture is diluted with water to about 50 ml and stirred for 2 h at room temperature. Thus resulting precipitates are separated by filtration, washed well with water and is dried under high vacuum to get solids of the title compound.

Workup

  1. temperatureunder heating
  2. stirringstirred for 2 h at room temperature
  3. customThus resulting
  4. customprecipitates
  5. customare separated by filtration
  6. washwashed well with water
  7. customis dried under high vacuum

Sources & evidence

ORD record
ord-1ea3343ebc6345da85d6e43274c3e5e0
Source dataset
uspto-grants-2016_06
Patent number
US09371333B2

Reaction notes

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