HCID 140620633, compound → HCID 69085097, compound

HRID 2206288Notes

Reaction equation

HRID 2206288 reaction equation
[NH2:1][C:2]1[O:3][C:4]2[C:9]([C:10](O)([C:19]3[CH:24]=[C:23]([O:25][CH3:26])[C:22]([O:27][CH3:28])=[C:21]([Br:29])[CH:20]=3)[C:11]=1[C:12]([NH:14][C:15](=[O:18])[CH2:16][Cl:17])=[NH:13])=[CH:8][CH:7]=[C:6]1[CH:31]=[CH:32][CH:33]=[CH:34][C:5]=21>C1(C)C(C)=CC=CC=1.O>[Br:29][C:21]1[CH:20]=[C:19]([CH:10]2[C:9]3[C:4](=[C:5]4[CH:34]=[CH:33][CH:32]=[CH:31][C:6]4=[CH:7][CH:8]=3)[O:3][C:2]([NH2:1])=[C:11]2[C:12]2[N:14]=[C:15]([CH2:16][Cl:17])[O:18][N:13]=2)[CH:24]=[C:23]([O:25][CH3:26])[C:22]=1[O:27][CH3:28]

Participants

4

Reactant 1

HCID 140620633HCID 140620633, compound

Product 1

HCID 69085097HCID 69085097, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 7237O-XyleneSolvent

Procedure

2-Amino-4-(3-bromo-4,5-dimethoxy-phenyl)-N-chloroacetylhydroxy-4H-benzo[h]chromene-3-carboxamidine (23) (137 mg, 0.25 mmol) is taken in 10 ml xylene and refluxed under LC-MS control and is stirred further at room temperature till the reaction is complete. The reaction mixture is diluted with water to about 50 ml and stirred for 2 h at room temperature. Thus resulting precipitates are separated by filtration, washed well with water and is dried under high vacuum to get solids of the title compound.

Workup

  1. temperaturerefluxed under LC-MS control
  2. stirringstirred for 2 h at room temperature
  3. customThus resulting
  4. customprecipitates
  5. customare separated by filtration
  6. washwashed well with water
  7. customis dried under high vacuum

Sources & evidence

ORD record
ord-1f4e2a46912c486ebc85c0d33dde38a9
Source dataset
uspto-grants-2016_06
Patent number
US09371333B2

Reaction notes

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