反应详情

Of the compound from Example 59A, 277 mg (0.91 mmol) were dissolved in 10 ml of dichloromethane and admixed at 0° C. with 0.7 ml (9.1 mmol) of trifluoroacetic acid, then stirred at room temperature for 1 hour. The mixture was concentrated on a rotary evaporator. The crude product was taken up in 20 ml of toluene and again concentrated on a rotary evaporator under reduced pressure. The crude product was purified by preparative HPLC [Method 19]. This gave 124 mg (43% of theory) of the target compound.

1. concentrationThe mixture was concentrated on a rotary evaporator
2. concentrationagain concentrated on a rotary evaporator under reduced pressure
3. customThe crude product was purified by preparative HPLC [Method 19]